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Insulin may contribute to the pathogenesis of hypertension by stimulating the sympathetic nervous system, promoting renal sodium retention, and/or stimulating vascular smooth muscle hypertrophy. These reactions are becoming rare (less than 1% of patients) due to the use of purer forms of pork insulin or biosynthetic human insulin. Patients on intensive insulin therapy have been more likely to experience weight gain. True allergy to insulin has been rare, and sensitization was usually associated with specific animal proteins in bovine and less pure forms of porcine insulins. Novolog Mix70/30 contains insulin aspart, a rapid-acting insulin, mixed with insulin aspart protamine, an intermediate-acting insulin.
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